Structure of recombinantly assembled A53E alpha-synuclein fibrils
Resolution: 3.38 Å
EM Method: Helical reconstruction
Fitted PDBs: 7uak
Q-score: 0.463
Sun C, Zhou K, DePaola IV P, Shin WS, Hillyer T, Sawaya MR, Zhu R, Peng C, Zhou ZH, Jiang L
J Biol Chem (2023) 299 pp. 104566-104566 [ Pubmed: 36871760 DOI: doi:10.1016/j.jbc.2023.104566 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein a53e mutant (59 MDa, Cellular component from Homo sapiens)
Structure of recombinantly assembled E46K alpha-synuclein fibrils
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 6ufr
Q-score: 0.656
Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS
PNAS (2020) 117 pp. 3592-3602 [ Pubmed: 32015135 DOI: doi:10.1073/pnas.1917914117 ]
- Water (18 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Recombinantly assembled e46k alpha-synuclein fibril (Cellular component from Homo sapiens)
Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril
Resolution: 3.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 6peo
Q-score: 0.544
Boyer DR, Li B, Sun C, Fan W, Sawaya MR, Jiang L, Eisenberg DS
Nat Struct Mol Biol (2019) 26 pp. 1044-1052 [ Pubmed: 31695184 DOI: doi:10.1038/s41594-019-0322-y ]
Cryo-EM structure of alpha-synuclein H50Q Wide Fibril
Resolution: 3.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 6pes
Q-score: 0.519
Boyer DR, Li B, Sun C, Fan W, Sawaya MR, Jiang L, Eisenberg DS
Nat Struct Mol Biol (2019) 26 pp. 1044-1052 [ Pubmed: 31695184 DOI: doi:10.1038/s41594-019-0322-y ]
Alpha Synuclein fibril formed by full length protein - Rod Polymorph
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 6cu7
Q-score: 0.447
Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L
Nat Commun (2018) 9 pp. 3609-3609 [ DOI: doi:10.1038/s41467-018-05971-2 Pubmed: 30190461 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein fibril - rod polymorph (Complex from Homo sapiens)
Alpha Synuclein fibril formed by full length protein - Twister Polymorph
Resolution: 3.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 6cu8
Q-score: 0.423
Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L
Nat Commun (2018) 9 pp. 3609-3609 [ DOI: doi:10.1038/s41467-018-05971-2 Pubmed: 30190461 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein fibril - twister polymorph (Complex from Homo sapiens)